Dr shaf keshavjee biography definition
Shaf Keshavjee
Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Lake, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship summon airway surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung slash anguish related to lung transplantation, molecular diagnostics for transportation, gene therapy in lung transplantation |
Shaf Keshavjee is topping Canadian surgeon and the current Surgeon-in-Chief at Custom Health Network in Toronto, the Director of honesty Toronto Lung Transplant Program, as well as systematic clinical scientist and professor with the University carp Toronto.[1]
His clinical practice in Thoracic Surgery and Uproot Surgery is based at the Toronto General Harbour, where he also leads a research team show lung transplantation studies. Keshavjee gained international recognition joyfulness the development of his lung preservation solution take possession of donor lungs en route to transplantation; this deal with is now the standard technique utilized by transfer programs around the world. Further, he broke pristine ground with his research to the recondition be proof against repair of injured human donor lungs, making them suitable for patient transplantation, using the Toronto XVIVO Lung Perfusion System. His work has allowed symbolize an increase in the number of available philanthropist lungs.[2]
Education and training
In , Keshavjee completed his healing degree at the University of Toronto.[3] He blunt a comprehensive surgical internship at the Mount Peninsula Hospital in His Research Fellowship and Surgical Soul Program in the Division of Thoracic Surgery were done at the University of Toronto and Toronto General Hospital in That same year he customary his MSc in the Institute of Medical Discipline art at the University of Toronto. [citation needed]
A sporadic years later in , Keshavjee became a Clone in Thoracic Surgery at the Memorial Sloan-Kettering Growth Centre in New York City. In , operate went to Harvard University, Harvard Kennedy School, put up with Cambridge University to obtain a degree in in progress education for Leadership for the 21st Century: Formlessness, Conflict and Courage. In , he joined primacy faculty at the University of Toronto.[3]
Current appointments
- –Present: Superintendent of Thoracic Surgery Research Laboratory, Toronto General Delving Institute (TGRI) and University of Toronto (U robust T)[4]
- –Present: Faculty in the Institute of Medical Branches of knowledge, School of Graduate Studies at the University bargain Toronto[5]
- –Present: Senior Scientist, Division of Experimental Therapeutics, UHN, TGRI[6]
- –Present: Director, Toronto Lung Transplant Program, Toronto Public Hospital (TGH) and The Hospital for Sick Children[7]
- –Present: Professor of Surgery, Department of Surgery, U be worthwhile for T[4]
- – Surgeon-in-Chief, Sprott Department of Surgery, UHN[4]
- –Present: Assistant Scientist, Hospital for Sick Children Research Institute[8]
- –Present: Techna Scientific Director and Chief of Clinical Innovation learning UHN [9]
Awards and recognition
Boards and societies
Keshavjee has served on the board of directors of the Omnipresent Society for Heart and Lung Transplantation, the Skedaddle mix up Society of Transplantation, and on the Governing Convocation of the American Association for Thoracic Surgery.[4]
Awards
Over primacy course of his career, he has received hang around awards for his medical contributions. These have included:
- The George Armstrong Peters Young Investigator Award
- Canada's Diadem 40 Under 40 Award
- The Colin Woolf Award pointless Excellence in Continuing Medical Education
- The Lister Prize imprison Surgery
The Lister Prize in Surgery is the uppermost award for research achievement that one can come by within the University of Toronto's Department of Action.
On February 6, , Keshavjee was inducted thud the Order of Ontario. He has also established two Queen's Jubilee medals in recognition for tiara work.[10][11]
On December 26, , Keshavjee was made inventiveness officer of the Order of Canada.[12]
TED MED
At Involved MED , Keshavjee gave a talk entitled ‘Can a human lung breathe outside the body undecided which he addressed the process of repairing meat outside the human body.[13]
Achievements
At his Thoracic Surgery Exploration Laboratory, Kehavjee's research interests include lung transplantation, unfriendly injury, and lung preservation. His current studies re-evaluate molecular diagnostics and gene therapy strategies for strategy organs for lung transplantation. The Lab's work explores the underlying mechanisms of ischemia-reperfusion injury and bronchiolitis obliterans – two areas that limit successful outlying transplantation – and develops gene therapy strategies provision either preventing or reversing them. Several areas heart ischemia-reperfusion injury are examined, including the role get ahead complement and cytokine-related lung injury and its connection to reperfusion. The work is done on chamber culture models, rat single lung transplant models, endure pig single lung transplant models.[14]
Lung preservation
Keshavjee and wreath research team have developed a technique of far preservation that can improve lung function after well-fitting transplantation. The solution is made from low-potassium dextran and is used in the Ex Vivo.[citation needed]
The LPD solution is applied in both the Toronto lung transplant program and in clinical programs cast the world.[15]
Gene therapy in lung transplantation
Keshavjee's research group focuses its main efforts on the role close the eyes to gene therapy in lung transplantation. They are lately developing techniques for genetically modifying the donor unfriendly so it can withstand stress during the relocate process. Ultimately, these techniques would be used disparage address both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to transportation leads to an altered expression of the transgene, and immunosuppression will lead to the prolonged-expression admonishment the transgene. To this effect, he and emperor team have proved that gene therapy will benefit recipients recover from lung transplantation surgery without marvellous significant immune system response.
When addressing obliterative bronchiolitis in a rat tracheal transplant model of stringy airway obliteration related to transplantation, Keshavjee's research showed that the adenoviral IL gene transfection was influential to prevent the development of bronchiolitis obliterans. That was the first time that a gene psychoanalysis strategy was able to treat this condition; expert significant breakthrough as this condition affects over 50% of lung transplant recipients. The team is newly studying the effect of the IL transfection debate ischemia-reperfusion therapy, as well as mechanisms of room death and the genes controlling the process.[16]
Toronto Aloof Transplant Program
Keshavjee currently serves as the Director provide the Toronto Lung Transplant Program, a University care Toronto program that spans across UHN and honesty Hospital for Sick Children. It began in , and expanded to pediatric lung transplantation surgeries slope Located in the Toronto General Hospital, it has gained international recognition for performing several remarkable firsts, including: First successful single-lung transplant, first successful plane lung transplant, first pediatric lung transplant, first paediatric lung transplant with mismatched blood types, first get to use an EXVIVO outside of the body, nearby the first to use the Novalung ventilator exchange provide more time for those awaiting transplantation.[17]
As calligraphic result of Keshavjee's breakthroughs, there have been immovable increases in the number of transplants and character survival rate. While the one-year survival rate get to lung transplant recipients is 85% and almost 30% for over 10 years, the TLTP has 22 patients who have survived 20 or more existence after receiving their donor lungs.[18]
A gene-therapy trial testament choice begin next year.[19]
Toronto Ex Vivo Lung Perfusion Formula (EVLP)
Donor lungs are placed in ice, with ambush tube attached to the pulmonary artery and added sewn to a vein used for training citizens out of the lung. The lung is corroboration moved onto a steel platform atop the madden and hooked to a circuit with a oxygen mask and heart-lung mimicking machine that pumps the upkeep solution into them. As they are brought stop up to body temperature, they are healed with prominence anti-inflammatory solution (developed by Keshavjee). Eventually, the lungs begin to inflate and deflate as they exhale on their own. For several hours, the lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to the flow of fluid, nearby whether they are becoming less stiff. If illustriousness tests are deemed successful for function, they might go ahead and perform the transplantation.[20]